May 29, 2012

Vasoactive intestinal polypeptidergic innervation of human urinary bladder in normal and pathological conditions.

Vasoactive intestinal polypeptidergic innervation of human urinary bladder in normal and pathological conditions.:
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Vasoactive intestinal polypeptidergic innervation of human urinary bladder in normal and pathological conditions.
Urol Int. 1988;43(4):205-10
Authors: Van Poppel H, Stessens R, Baert L, Van Damme B, Carton H
Urinary bladder biopsies from 31 multiple sclerosis patients, 9 diabetics, 5 patients after transtrigonal phenolization and 20 control patients were stained for acetylcholinesterase, S100 and vasoactive intestinal polypeptide (VIP). The VIP immunoreactivity was not decreased in all neuropathic bladders and its depletion was not related to cholinergic depletion. There was no correlation between bladder over- or underactivity and VIP content. VIP can act as a modulator of detrusor function in normal conditions. The significance of its depletion in neurogenic bladders needs further elaboration.
PMID: 3188288 [PubMed - indexed for MEDLINE]

May 15, 2012

May 7, 2012

Incontinence of urine due to instability of micturition reflexes: Part I. Detrusor reflex instability.

Incontinence of urine due to instability of micturition reflexes: Part I. Detrusor reflex instability.:
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Incontinence of urine due to instability of micturition reflexes: Part I. Detrusor reflex instability.
Urology. 1980 Mar;15(3):229-39
Authors: Mahony DT, Laferte RO, Blais DJ
Micturition reflex instability may result from malfunction of the detrusor reflex or instability of the pudendal nucleus which innervates the pelvic floor muscles and external sphincter. Detrusor instability is the result of sacral micturition reflex center (SMRC) hyperexcitability. This may be caused by underinhibition or overfacilitation of the SMRC, and there are both central and peripheral causes of each. Detrusor hypertrophy may invoke chronic overactivity of the detrusodetrusor facilitative reflex causing SMRC overfacilitation. Similarly, distal urethral stricture and/or chronic urethritis causing chronic overactivity of the urethrodetrusor facilitative reflex is a common cause of SMRC overfacilitation. Pathologic relaxation and weakness of the striated muscles of the pelvic floor and perineum resulting in underactivity of the perineodetrusor inhibitory reflex, is a common cause of SMRC underinhibition. In adult women these factors often coexist. Each may predispose to stress-induced detrusor instability and are often seen in association with, or are confused with, true stress incontinence. The distinguishing characteristics of detrusor hypertonicity and detrusor hyperreflexia are reviewed, and the various mechanisms of pseudostress incontinence and of urgency incontinence are discussed in detail.
PMID: 7189070 [PubMed - indexed for MEDLINE]