May 30, 2016

A ventral root avulsion injury model for neurogenic underactive bladder studies.

A ventral root avulsion injury model for neurogenic underactive bladder studies.
Exp Neurol. 2016 May 21;
Authors: Chang HH, Havton LA
Abstract
Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration during bladder emptying and results in incomplete and prolonged bladder emptying. The clinical diagnosis of DU is challenging when present alone or in association with other bladder conditions such as detrusor overactivity, urinary retention, detrusor hyperactivity with impaired contractility, aging, and neurological injuries. Several etiologies may be responsible for DU or the development of an underactive bladder (UAB), but the pathobiology of DU or UAB is not well understood. Therefore, new clinically relevant and interpretable models for studies of UAB are much needed in order to make progress towards new treatments and preventative strategies. Here, we review a neuropathic cause of DU in the form of traumatic injuries to the cauda equina (CE) and conus medullaris (CM) portions of the spinal cord. Lumbosacral ventral root avulsion (VRA) injury models in rats mimic the clinical phenotype of CM/CE injuries. Bilateral VRA injuries result in bladder areflexia, whereas a unilateral lesion results in partial impairment of lower urinary tract and visceromotor reflexes. Surgical re-implantation of avulsed ventral roots into the spinal cord and pharmacological strategies can augment micturition reflexes. The translational research need for the development of a large animal model for UAB studies is also presented, and early studies of lumbosacral VRA injuries in rhesus macaques are discussed.
PMID: 27222131 [PubMed - as supplied by publisher]
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May 19, 2016

Re: The Underactive Bladder: A New Clinical Concept?

Re: The Underactive Bladder: A New Clinical Concept?
J Urol. 2016 Jun;195(6):1831
Authors: Wein AJ
PMID: 27191085 [PubMed - as supplied by publisher]
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May 16, 2016

Meningitis-retention Syndrome; A Case Report.

Meningitis-retention Syndrome; A Case Report.
Urol Case Rep. 2016 May;6:42-4
Authors: Ishii G, Hata K, Aoki S, Suzuki M, Kimura T, Egawa S
Abstract
We report a case of meningitis-retention syndrome followed by urodynamic tests. A 48-year-old man was admitted to the hospital for an undiagnosed fever with headache and urinary retention. Aseptic meningitis was suspected according to cerebrospinal fluid analyses, and urodynamic test showed an underactive detrusor, leading to inadequate contraction of the bladder on voiding in spite of a normal sensation during bladder filling. Clean intermittent self-catheterization was required temporarily, but normal urinary voiding without the need for medication was restored in 2 weeks after discharge from the hospital, when urodynamic tests showed normal contractility of the bladder during voiding. 
PMID: 27175342 [PubMed]
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